Medicine and Mice Research All Week Long for Astro-Scientists

The Bahamas
The clear blue waters surrounding the islands of the Bahamas were pictured April 4, 2018 from an Expedition 55 crew member aboard the space station.

Scientists on the ground and in space this week are exploring a wide variety of phenomena affecting humans living in space. The ongoing life science aboard the International Space Station is designed to improve astronauts’ health in space and benefit people on Earth.

Medicine plays an important role in an astronaut’s health and doctors want to know more about how drug therapies work in space. NASA Flight Engineer Drew Feustel supported the medicine research today and injected human tissue samples with a drug compound for the Metabolic Tracking study. Those samples will be incubated then frozen before returning to Earth to be analyzed. Results may help the pharmaceutical industry design better, cheaper drugs for humans on Earth and in space.

Japanese astronaut Norishige Kanai is tending to mice today, cleaning their habitats and preparing for a week-long run of the Mouse Stress Defense experiment. The Expedition 55 crew and doctors on Earth are observing the mice to understand the processes leading to muscle and bone loss in microgravity. Researchers are testing therapies that may prevent the physiological signals and stresses in space that lead to a weakened musculoskeletal system.

Other important space research taking place throughout the week will look at how plants grow off Earth possibly sustaining future crews and improving Earth agriculture. The crew will also test the new Miniature Exercise Device-2 for providing a range of motion and resistance exercise while taking up less space aboard the station.

More external cargo operations took place outside the SpaceX Dragon resupply ship over the weekend. Robotics controllers remotely operating the Canadarm2 stowed a failed pump flow control sub-assembly (PFCS) in Dragon’s trunk ahead of a May spacewalk. That spacewalk will see two astronauts work outside the station to relocate a series of spare sub-assemblies for functional testing.


Get weekly video highlights at: http://jscfeatures.jsc.nasa.gov/videoupdate/

New Book Offers Inside Look at Station Flight Controllers

Operating an Outpost in the New Frontier
The International Space Station: Operating an Outpost in the New Frontier, is now available to download for free at https://go.usa.gov/xQbvH

Ever wanted a deeper dive into the life of the International Space Station? The flight directors in charge of the teams that oversee its systems have written a 400-page book that offers an inside look at the time and energy the flight control team at the Mission Control Center at NASA’s Johnson Space Center in Houston devote to the development, planning and integration of a mission.

The International Space Station: Operating an Outpost in the New Frontier, is now available to download for free at https://go.usa.gov/xQbvH.

Here’s an excerpt from the book to give you a taste of what to expect:

Chapter 10: Preparing for the Unexpected

At 2:49 a.m. Central Standard Time, a red alarm illuminated the giant front wall display in Mission Control in Houston. The alert read: TOXIC ATMOSPHERE Node 2 LTL IFHX NH3 Leak Detected.

The meaning was clear. Ammonia was apparently leaking into the Interface Heat Exchanger (IFHX) of the Low Temperature cooling Loop (LTL) in the Node 2 module.

“Flight, ETHOS, I expect the crew to be pressing in emergency response while I confirm,” said the flight controller from Environmental and Thermal Operating Systems (ETHOS). In other words, the crew needed to don oxygen masks to protect themselves from ammonia while ETHOS looked more closely at these data.

This was not a drill. When the red alarm appeared, the flight director turned her full attention to ETHOS. The words—unwelcome at any time from ETHOS—were especially jarring at an hour when the crew and the ground were humming along on a busy day of running experiments. Of the many failures for which the flight control team prepares, especially in simulations, this failure presents one of the most life-threatening situations, and one the team never wants to encounter on the actual vehicle.

On January 14, 2015, this scenario happened on the International Space Station (ISS). Data on the ETHOS console indicated toxic ammonia could be bleeding in from the external loops, through the waterbased IFHX, and into the cabin (see Chapter 11). Software on the ISS immediately turned off the fans and closed the vents between all modules to prevent the spread of ammonia. At the sound of the alarm, crew members immediately began their memorized response of getting to the Russian Segment (considered a safe haven, since that segment does not have ammonia systems) and closed the hatch that connected to the United States On-orbit Segment (USOS). They took readings with a sensitive sensor to determine the level of ammonia in the cabin. The flight control team—especially the flight director, ETHOS, and the capsule communicator (CAPCOM [a holdover term from the early days of the space program])—waited anxiously for the results while they looked for clues in the data to see how much, if any, ammonia was entering the cabin. Already, the flight director anticipated multiple paths that the crew and ground would take, depending on the information received.

No ammonia was detected in the cabin of the Russian Segment. At the same time, flight control team members looked at multiple indications in their data and did not see the expected confirming cues of a real leak. In fact, it was starting to look as if an unusual computer problem was providing incorrect readings, resulting in a false alarm. After looking carefully at the various indications and starting up an internal thermal loop pump, the team verified that no ammonia had leaked into the space station. The crew was not in danger. After 9 hours, the flight control team allowed the crew back inside the USOS. However, during the “false ammonia event,” as it came to be called, the team’s vigilance, discipline, and confidence came through. No panicking. Only measured responses to quickly exchange information and instructions.

Hearts were pumping rapidly, yet onlookers would have noticed little difference from any other day.

A key to the success of the ISS Program is that it is operated by thoroughly trained, well-prepared, competent flight controllers. The above example is just one of many where the team is unexpectedly thrust into a dangerous situation that can put the crew at risk or jeopardize the success of the mission. Both the flight controllers and the crews, often together, take part in simulations. Intense scenarios are rehearsed over and over again so that when a real failure occurs, the appropriate reaction has become second nature.

After these types of simulations, team members might figure out a better way to do something, and then tuck that additional knowledge into their “back pocket” in the event of a future failure. Perhaps the most famous example of this occurred following a simulation in the Apollo Program. After the instructor team disabled the main spacecraft, the flight controllers began thinking about using the lunar module as a lifeboat. When the Apollo 13 spacecraft was damaged significantly by an exploding oxygen tank, the flight control team already had some rough ideas as to what they might do. Since the scenario was not considered likely owing to all the safety precautions, the team had not developed detailed procedures. However, the ideas were there.

Keep reading at https://go.usa.gov/xQbvH.

More Human Research as Dragon Offers New Earth Observation Gear

SpaceX Dragon Space Freighter
The SpaceX Dragon resupply ship, with the 57.7-foot-long Canadarm2 robotic arm in the foreground, is pictured installed to the Harmony module’s Earth-facing port.

The Expedition 55 crew continued exploring today the numerous ways the human body is affected when living in space long-term. More cargo transfers are also taking place both inside and outside the SpaceX Dragon resupply ship.

NASA Flight Engineer Scott Tingle processed human tissue cultures for the Metabolic Tracking (MT) experiment to help doctors understand how medicine impacts astronauts.  His fellow NASA astronaut Ricky Arnold looked at a set of different biological samples for the student-built Genes in Space-5 experiment. That study is researching if DNA alterations and a weakened immune system are connected due to microgravity.

Arnold later joined Flight Engineer Drew Feustel for a routine eye exam with a fundoscope to get a good look at their retinas. The duo also worked to unload more cargo from Dragon which has been attached to the Harmony module since April 4.

Back on the ground at Mission Control in Houston, robotics engineers are working to remotely extract the Atmosphere-Space Interactions Monitor (ASIM) experiment from Dragon’s trunk. They are operating the Canadarm2 to detach ASIM, an Earth observation facility, from Dragon and install it on the Columbus laboratory module. ASIM will study severe thunderstorms and their role in the Earth’s atmosphere and climate.

Crew Researching Plants, Medicine and Unloading New Science from Dragon

NASA astronaut and Flight Engineer Ricky Arnold
NASA astronaut and Flight Engineer Ricky Arnold works with the student-designed Genes in Space-5 experiment inside the Harmony module. The genetic research is helping scientists understand the relationship between DNA alterations and weakened immune systems possibly caused by living in space.

Today’s research aboard the International Space Station is primarily focusing on how plants react and how medicine works in space. The Expedition 55 crew and robotics controllers are also continuing cargo operations inside and outside the SpaceX Dragon cargo craft.

Flight Engineer Ricky Arnold participated today in the Plant Gravity Perception experiment, one of several ongoing space botany studies. The station crew is helping scientists explore how plants determine which way to grow and perceive light in microgravity. Results may help future astronauts training for longer missions beyond low-Earth orbit learn how to grow crops in space to sustain themselves.

Japanese astronaut Norishige Kanai continued research into how the human body in space metabolizes medicine. NASA astronaut Drew Feustel started operations with the Metabolic Tracking (MT) experiment this morning before handing it off to Kanai. MT is looking at a particular type of medicine and how it interacts with human tissue cultures. Results could improve therapies in space and lead to better, cheaper drugs on Earth.

Scott Tingle of NASA partnered with Arnold today unloading more cargo from Dragon. They continue to unpack several thousand pounds of new science experiments, station hardware and crew supplies.

Outside the Dragon in its trunk is the Atmosphere-Space Interactions Monitor (ASIM) experiment that will be robotically removed Friday. Engineers on the ground operating the Canadarm2 will maneuver ASIM, an Earth observation facility, and install it on Europe’s Columbus lab module.

Variety of Life Studied to Benefit Humans on Earth and in Space

Daybreak and Aurora
Daybreak begins to interrupt this aurora as the International Space Station flies an orbital day pass.

The Expedition 55 crew explored a wide variety of life science today studying how different biological systems are affected by long-term exposure to microgravity. The multi-faceted space residents observed human genetic and tissue samples, rodents and fruit flies aboard the orbital laboratory today.

Flight Engineer Ricky Arnold started his morning gearing up the student-designed Genes in Space-5 experiment. He processed hardware and genetic samples to help scientists understand the relationship between DNA alterations and weakened immune systems possibly caused by living in space.

Arnold later joined fellow NASA astronaut Drew Feustel for ultrasound eye exams with remote assistance from doctors on the ground. Feustel wrapped up his workday checking on fruit flies housed in the Multi-Use Variable-G Platform that enables research into smaller and microscopic organisms.

Norishige Kanai, from the Japan Aerospace Exploration Agency, tended to mice recently launched to space aboard the SpaceX Dragon cargo craft. The rodents are part of the Mouse Stress Defense experiment that tests strategies to counteract microgravity stresses and cell signaling that lead to bone and muscle loss.

Doctors are learning how medicine works in space and what it does inside astronaut’s bodies. NASA Flight Engineer Scott Tingle looked at a particular type of medicine today and how it interacts with human tissue cultures. Results could improve therapies in space and lead to better, cheaper drugs on Earth.

Crew Researches Biology and Physics, Practices for Emergency

Italy and the Mediterranean Sea
This oblique view taken above southeastern Europe looks west over Italy and into the Mediterranean Sea toward France and Spain.

The fully-staffed Expedition 55 crew worked throughout the International Space Station today exploring how microgravity affects a variety of phenomena including biology and physics. The six long-term space residents also practiced a simulated emergency today to maintain their safety skills and awareness.

Flight Engineer Drew Feustel started Tuesday collecting a urine sample and stowing it inside the Human Research Facility’s (HRF) science freezer for later analysis. Shortly afterward, Japanese astronaut Norishige Kanai inserted a dosimeter and biological samples in the HRF’s freezer to research the effects of cosmic radiation on mammalian reproduction.

Commander Anton Shkaplerov swapped manifold bottles inside the Combustion Integrated Rack, a device that enables the safe observation of flames and soot on the orbital laboratory. Shkaplerov’s work today is in support of the Advanced Combustion Microgravity Experiment (ACME). ACME is a set of five independent studies researching gaseous flames in space that may enable more fuel efficient and less polluting technologies on Earth.

NASA astronaut Scott Tingle unpacked new medicine for the crew from the SpaceX Dragon resupply ship today. He also packed up and stowed expired or unused medicine back inside Dragon for return and disposal back on Earth.

The entire crew got together in the middle of the day and trained for the unlikely event of an emergency aboard the orbital lab today. The four astronauts and two cosmonauts practiced communication coordination and familiarized themselves with the location of response areas and safety gear.

Meanwhile, robotics flight controllers are remotely swapping Pump Flow Subassemblies on the outside of the station. They are removing a spare launched on Dragon and replacing it with a failed unit on the Port 6 truss. This is the first of a series of maneuvers that will culminate with another swap of components during the next spacewalk in mid-May.

Dragon Opens Up Offering New Space Research

Astronauts Watch Dragon Arrive
Astronauts Scott Tingle (left) and Norishige Kanai watch the SpaceX Dragon cargo craft arrive moments before capturing it with the Canadarm2 robotic arm.

The SpaceX Dragon space freighter is open for business today as the Expedition 55 crew begins unloading and activating new time-sensitive space experiments aboard the International Space Station.

Astronaut Scott Tingle opened Dragon’s hatch this morning and was the first to enter the spaceship. He and fellow NASA astronauts Drew Feustel and Ricky Arnold began offloading new science gear immediately afterward. Japanese astronaut Norishige Kanai tended to new mice shipped aboard Dragon and transferred them to habitats located inside Japan’s Kibo laboratory module.

Some of the new space studies will enable research into a variety of biological organisms to understand microgravity’s long term effects on life systems. Scientists hypothesize their observations will benefit both crews in space and people on Earth. Other experiments will study physics phenomena both inside and outside the orbital lab with potential impacts on future space systems and industrial and manufacturing processes on the ground.

Robotics operators on the ground will command the Canadarm2 robotic arm to ungrip the newly-installed Dragon today. They will remotely maneuver the Canadarm2 on Friday to extract unpressurized cargo, including life support gear and external research, from Dragon’s exposed aft-end, also called its trunk. Dragon will remain attached to the Harmony module’s Earth-facing port until early May.

Dragon Bolted to Station’s Harmony Module

April 4, 2018: International Space Station Configuration
Four spaceships are docked at the space station including the SpaceX Dragon space freighter, the Progress 69 resupply ship and the Soyuz MS-07 and MS-08 crew ships.

Two days after its launch from Florida, the SpaceX Dragon cargo spacecraft was installed on the Harmony module of the International Space Station at 9:00 a.m. EDT.

The 14th contracted commercial resupply mission from SpaceX (CRS-14) delivered about 5,800 pounds of research, crew supplies and hardware to the orbiting laboratory.

Among the research arriving to the U.S. National Laboratory is a Metabolic Tracking investigation to evaluate the use of a new method to test, in microgravity, the metabolic impacts of pharmaceutical drugs. This could lead to more effective, less expensive medicines on Earth. The Multi-use Variable-g Platform (MVP) will serve as a new test bed aboard the space station, able to host 12 separate experiment modules with samples such as plants, cells, protein crystals and fruit flies. The Center for the Advancement of Science in Space (CASIS), which manages the U.S. National Laboratory, is sponsoring the investigation and the MVP.

Dragon will remain attached to the space station until May, when it will return to Earth with more than 3,500 pounds of research, hardware and crew supplies.

Keep up to date with the latest news from the crew living in space by following https://blogs.nasa.gov/spacestation/, @space_station and @ISS_Research on Twitter, and the ISS Facebook and ISS Instagram accounts.

Astronauts Capture Dragon Resupply Ship

SpaceX Dragon Capture
The SpaceX Dragon was grappled by the Canadarm2 robotic arm today as the space station orbited above the continent of Africa. Credit: NASA TV

While the International Space Station was traveling more than 250 miles over the southern part of the Democratic Republic of the Congo in Africa, Japan Aerospace Exploration Agency astronaut Norishige Kanai and NASA astronaut Scott Tingle captured the Dragon spacecraft at 6:40 a.m. EDT using the space station’s Canadarm2 robotic arm.

Ground controllers will now send commands to begin the robotic installation of the spacecraft on the station’s Harmony module. NASA Television coverage of installation will begin at 8:30 a.m. Watch online at www.nasa.gov/live.

The Dragon lifted off on a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station in Florida Monday, April 2 with more than 5,800 pounds of research investigations and equipment, cargo and supplies to support dozens of the more than 250 investigations aboard the space station during Expeditions 55 and 56.

Among the research arriving on Dragon is a new facility to test materials, coatings and components, or other large experiments, in the harsh environment of space. Designed by Alpha Space and sponsored by the Center for the Advancement of Science in Space, the Materials ISS Experiment Flight Facility (MISSE-FF) provides a platform for testing how materials react to exposure to ultraviolet radiation, atomic oxygen, ionizing radiation, ultrahigh vacuum, charged particles, thermal cycles, electromagnetic radiation, and micro-meteoroids in the low-Earth orbit environment.

The Canadian Space Agency’s study Bone Marrow Adipose Reaction: Red or White (MARROW) will look at the effects of microgravity on bone marrow and the blood cells it produces – an effect likened to that of long-term bed rest on Earth. The extent of this effect, and bone marrow’s ability to recover when back on Earth, are of interest to space researchers and healthcare providers alike.

Dragon also is carrying an Earth observatory that will study severe thunderstorms and their role in the Earth’s atmosphere and climate, as well as upgrade equipment for the station’s carbon dioxide removal system, external high-definition camera components, and a new printer for the station’s crew.

Keep up to date with the latest news from the crew living in space by following https://blogs.nasa.gov/spacestation/, @space_station and @ISS_Research on Twitter, and the ISS Facebook and ISS Instagram accounts.

Resupply Ship Midway to Station Amid Maintenance and Science Work

The "Horn of Africa"
The “Horn of Africa” is seen through one of the seven windows that make up the Cupola, a dome-shaped module on the International Space Station. The space station crew will be inside the Cupola Wednesday morning operating a robotics workstation to capture the upcoming SpaceX Dragon.

The SpaceX Dragon space freighter is midway on its trip to the resupply the International Space Station’s Expedition 55 crew. Waiting to capture Dragon Wednesday morning are Flight Engineers Norishige Kanai and Scott Tingle.

The two astronauts have been reviewing procedures and training on a computer for Dragon’s capture for a few weeks now. Kanai will command the Canadarm2 robotic arm to reach out and grapple Dragon about 7 a.m. EDT Wednesday when it reaches a point about 10 meters away from the station. Tingle is backing up Kanai and will monitor Dragon’s approach and rendezvous from inside the Cupola. Flight Engineer Ricky Arnold will be assisting the duo by overseeing approach telemetry from a communications unit on the space station. NASA TV will begin its live mission coverage starting at 5:30 a.m.

Dragon is carrying a variety of cargo including new science experiments researching the human body, plants and how materials react when exposed to space. The Marrow study will explore bone marrow and the blood cells it produces. PONDS will explore ways to achieve uniform plant growth as astronauts supplement their diets with fresh space-grown greens. The Materials ISS Experiment Flight Facility, or MISSE-FF, will observe what happens to materials exposed to outer space phenomena such as ultraviolet radiation, charged particles and micro-meteoroids.

Meanwhile, the six space station residents are keeping the orbital lab in tip-top shape today while continuing ongoing scientific studies. Commander Anton Shkaplerov stayed focused on maintenance duties in the station’s Russian segment. New Expedition 55 crew members Ricky Arnold, Drew Feustel and Oleg Artemyev had time set aside to get used to their new home in space.

Tingle swapped out Combustion Integrated Rack hardware in the Destiny lab module. Kanai readied mouse habitat gear for a rodent study being delivered on Dragon. Kanai and Tingle later ended the day with more Dragon robotics practice.